Ngoan L T, Mizoue T, Fujino Y, Tokui N, Yoshimura T
Department of Clinical Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
Br J Cancer. 2002 Jul 1;87(1):37-42. doi: 10.1038/sj.bjc.6600415.
The present study examined the relationship between stomach cancer and the low intake of fresh fruit and vegetables and/or a high intake of pickled, preserved or salted foods and frequent use of cooking oil. During 139,390 person-year of follow-up of over 13,000 subjects, 116 died from stomach cancer. Using a Cox proportional hazards-regression analysis of relative risk (RR, 95% CI) controlling for age, sex, smoking and other dietary factors, a significant decline was found with a high consumption of green and yellow vegetables (RR=0.4, 95% CI=0.2-0.9). Reductions of between 40 and 50% were also observed with a high consumption of fresh foods (fruit, cuttle fish, tofu, and potatoes), but these associations were not statistically significant. The risk was significantly increased by the high consumption of processed meat (RR=2.7, 95% CI=1.0-7.4) and by the frequent use of cooking oil (RR=4.0, 95% CI=1.3-11.8). The high consumption of pickled food and traditional soups also increased risk, but not significantly. The findings suggest that a diet high in salt and low in vitamins may be associated with an increase in stomach cancer.
本研究调查了胃癌与新鲜水果和蔬菜摄入量低、和/或腌制、加工或盐渍食品摄入量高以及频繁使用食用油之间的关系。在对13000多名受试者进行的139390人年的随访期间,有116人死于胃癌。通过Cox比例风险回归分析相对风险(RR,95%置信区间),并对年龄、性别、吸烟和其他饮食因素进行控制,发现大量食用绿色和黄色蔬菜会使风险显著降低(RR=0.4,95%置信区间=0.2 - 0.9)。大量食用新鲜食品(水果、墨鱼、豆腐和土豆)也观察到风险降低了40%至50%,但这些关联在统计学上并不显著。加工肉类的大量食用(RR=2.7,95%置信区间=1.0 - 7.4)和频繁使用食用油(RR=4.0,95%置信区间=1.3 - 11.8)会使风险显著增加。腌制食品和传统汤品的大量食用也会增加风险,但不显著。研究结果表明,高盐和低维生素饮食可能与胃癌风险增加有关。