Lin Yingsong, Kikuchi Shogo, Obata Yuki, Yagyu Kiyoko
Department of Public Health, Aichi Medical University School of Medicine, 21 Karimata, Yazako, Nagakute-cho, Aichi-gun, Aichi 480-1195, Japan.
Jpn J Cancer Res. 2002 Oct;93(10):1071-5. doi: 10.1111/j.1349-7006.2002.tb01207.x.
We conducted a case-control study to evaluate the association between serum levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and the risk of gastric cancer. Cases were 214 patients who had been diagnosed with gastric cancer and controls were 120 persons who underwent medical checkups. Serum levels of Cu/Zn SOD were determined by enzyme-linked immunosorbent assay (ELISA). Compared with the lowest quartile, the OR (odds ratio) was 4.54 (95% CI (confidence interval), 1.62 - 12.66) for the third quartile and 15.75 (95% CI, 5.84 - 42.46) for the highest quartile. With both early and advanced cancers, as well as with the intestinal and diffuse types, a significant increase in risk was observed with increasing levels of serum Cu/Zn SOD. Our case-control study showed that serum levels of Cu/Zn SOD were significantly elevated in gastric cancer patients compared with apparently healthy controls, and higher Cu/Zn SOD levels may be associated with an increased risk of gastric cancer.
我们进行了一项病例对照研究，以评估血清铜/锌超氧化物歧化酶（Cu/Zn SOD）水平与胃癌风险之间的关联。病例为214例已被诊断为胃癌的患者，对照为120例接受体检的人。通过酶联免疫吸附测定（ELISA）测定血清Cu/Zn SOD水平。与最低四分位数相比，第三四分位数的OR（比值比）为4.54（95%CI（置信区间），1.62 - 12.66），最高四分位数的OR为15.75（95%CI，5.84 - 42.46）。在早期和晚期癌症以及肠型和弥漫型癌症中，均观察到随着血清Cu/Zn SOD水平升高，风险显著增加。我们的病例对照研究表明，与明显健康的对照相比，胃癌患者血清Cu/Zn SOD水平显著升高，且较高的Cu/Zn SOD水平可能与胃癌风险增加有关。
