Pournaras Spyros, Tsakris Athanassios, Maniati Maria, Tzouvelekis Leonidas S, Maniatis Antonios N
Department of Medical Microbiology, University of Thessaly, Larissa, Greece.
Antimicrob Agents Chemother. 2002 Dec;46(12):4026-8. doi: 10.1128/AAC.46.12.4026-4028.2002.
A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla(VIM-4), a novel variant of bla(VIM-1), with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.
从希腊一名术后脑脊液感染患者身上分离出一株对碳青霉烯类高度耐药的铜绿假单胞菌。该分离株携带一个1类整合子，其中仅包含一个基因盒bla(VIM-4)，它是bla(VIM-1)的一个新变体，有一个核苷酸差异，导致VIM-1酶的第175位氨基酸由丝氨酸变为精氨酸。这是VIM-1变体在意大利出现后首次被检测到。
