Fukushima S, Hirose M, Tsuda H, Shirai T, Hirao K
Gan. 1976 Feb;67(1):81-90.
Histological types and grades of 613 urinary bladder cancers induced in rats by N-butyl-N-(4-hydroxybutyl) nitrosamine(BBN) were analyzed. Most of them (95.1%) were transitional cell carcinomas, the remainder being squamous cell carcinomas (3.3%), undifferentiated carcinomas (2.5%), and carcinosarcomas (0.3%). Among the transitional cell carcinomas, 23.3% were Grade I anaplasia, 55.2% Grade II, and 21.5% Grade III. Among the squamous cell carcinomas, 20% each were Grade I and II, and 60% Grade III. Most of the undifferentiated carcinomas were Grade III. Some of the cases of transitional cell carcinoma had areas of squamous metaplasia and/or glandular metaplasia, and the incidence of metaplasia increased with the grade of anaplasia. Approximately 36% of the cases of transitional cell carcinoma were of the invasive type. Invasive types were twice as numerous among cases of squamous cell carcinoma as among those of transitional cell carcinoma and all of undifferentiated carcinomas were invasive. The incidence of invasive type was closely related to the grade of anaplasia. These results show that the morphological characteristics of urinary bladder carcinomas induced by BBN in rats are similar to those seen clinically in humans.
对用N-丁基-N-(4-羟丁基)亚硝胺（BBN）诱导的613例大鼠膀胱癌的组织学类型和分级进行了分析。其中大多数（95.1%）为移行细胞癌，其余为鳞状细胞癌（3.3%）、未分化癌（2.5%）和癌肉瘤（0.3%）。在移行细胞癌中，23.3%为I级间变，55.2%为II级，21.5%为III级。在鳞状细胞癌中，I级和II级各占20%，III级占60%。大多数未分化癌为III级。部分移行细胞癌病例有鳞状化生和/或腺化生区域，化生发生率随间变程度增加而升高。约36%的移行细胞癌病例为浸润型。鳞状细胞癌病例中浸润型的数量是移行细胞癌病例中的两倍，所有未分化癌均为浸润型。浸润型发生率与间变程度密切相关。这些结果表明，BBN诱导的大鼠膀胱癌的形态学特征与人类临床所见相似。
