Han Quan-Bin, Li Ma-Lin, Li Sheng-Hong, Mou Yi-Kun, Lin Zhong-Wen, Sun Han-Dong
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
Chem Pharm Bull (Tokyo). 2003 Jul;51(7):790-3. doi: 10.1248/cpb.51.790.
Four new ent-kaurane diterpenoids lushanrubescensins F-I (1-4), together with 11 known ones, lasiodonin (5), oridonin (6), ponicidin (7), isodonoiol (8), isodonal (9), rabdosin B (10), rabdoternins A and B (11 and 12), enmenol (13), epinodosin (14), and inflexusin (15), were isolated from Isodon rubescens var. lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated.
从庐山香茶菜中分离得到4个新的对映-贝壳杉烷二萜类化合物庐山香茶菜素F-I（1-4），以及11个已知化合物，分别为毛萼乙素（5）、冬凌草甲素（6）、ponicidin（7）、香茶菜醇（8）、异冬凌草素（9）、蓝萼甲素（10）、毛萼甲素和毛萼乙素（11和12）、延命草素（13）、表蓝萼甲素（14）和弯锥香茶菜素（15），并通过光谱分析对其结构进行了鉴定。评估了化合物3和5-10对K562、Bcap37、BGC823、BIU87、CA、CNE和Hela细胞系的抑制作用。
