Zhang Hai-Bo, Pu Jian-Xin, Wang Yuan-Yuan, He Fei, Zhao Yong, Li Xiao-Nian, Luo Xiao, Xiao Wei-Lie, Li Yan, Sun Han-Dong
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Chem Pharm Bull (Tokyo). 2010 Jan;58(1):56-60. doi: 10.1248/cpb.58.56.
Four new 7, 20-epoxy-ent-kauranoids, rubluanins A-D (1-4) and eleven known ones, were isolated from Isodon rubescens var. lushanensis, and their structures were elucidated by spectroscopic analysis. Compounds 2-14 were evaluated for their cytotoxicity in several human tumor cell lines (U937, Jurkat, HL-60, K562, SGC790, and HepG2). Among the compounds, lasiokaurin (13) showed significant cytotoxic activity of 0.62 microM (IC(50)) in U937 cells.
从庐山香茶菜中分离得到4个新的7,20-环氧-对映-贝壳杉烷型二萜，即鲁布蓝素A-D（1-4）以及11个已知化合物，通过光谱分析对其结构进行了鉴定。对化合物2-14在几种人肿瘤细胞系（U937、Jurkat、HL-60、K562、SGC790和HepG2）中进行了细胞毒性评价。其中，毛萼香茶菜素（13）在U937细胞中表现出显著的细胞毒性活性，IC50为0.62 μM。
