猪呼吸道冠状病毒与猪流感病毒同时感染猪的致病性。
Pathogenicity of concurrent infection of pigs with porcine respiratory coronavirus and swine influenza virus.
作者信息
Lanza I, Brown I H, Paton D J
机构信息
Ministry of Agriculture, Fisheries and Food, Central Veterinary Laboratory, New Haw, Addlestone, Surrey.
出版信息
Res Vet Sci. 1992 Nov;53(3):309-14. doi: 10.1016/0034-5288(92)90131-k.
Abstract
Combinations of porcine respiratory coronavirus (PRCV) and either of two swine influenza viruses (H1N1 or H3N2) were administered intranasally and by aerosol to six- to eight-week-old specific pathogen-free pigs. The clinical responses, gross respiratory lesions and growth performances of these pigs were studied and compared with those of single (PRCV, H1N1 or H3N2) and mock-infected animals. PRCV infection caused fever, growth retardation and lung lesions, but no respiratory symptoms. Infection with swine influenza viruses caused rather similar, mild symptoms of disease, with H1N1 infection being the least severe. Combined infections with influenza viruses and PRCV did not appear to enhance the pathogenicity of these viruses. Furthermore, viruses were isolated more frequently from tissues and nasal swabs taken from 'single' than 'dual' infected animals, suggesting a possible in vivo interference between replication of PRCV and swine influenza virus.
摘要
将猪呼吸道冠状病毒（PRCV）与两种猪流感病毒（H1N1或H3N2）之一的组合经鼻内和气溶胶方式接种到6至8周龄的无特定病原体猪体内。研究了这些猪的临床反应、呼吸道大体病变和生长性能，并与单一（PRCV、H1N1或H3N2）感染及 mock 感染动物进行比较。PRCV感染导致发热、生长迟缓及肺部病变，但无呼吸道症状。猪流感病毒感染引起相当类似的轻度疾病症状，其中H1N1感染最不严重。流感病毒与PRCV的联合感染似乎并未增强这些病毒的致病性。此外，从“单一”感染动物的组织和鼻拭子中分离病毒的频率高于“双重”感染动物，这表明PRCV与猪流感病毒复制之间可能存在体内干扰。
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