一种理解酒精中毒的遗传和神经生物学基础的实验方法。
An experimental approach to understanding the genetic and neurobiological basis of alcoholism.
作者信息
Li T K, Lumeng L, McBride W J, Murphy J M
机构信息
Indiana University School of Medicine, Indianapolis.
出版信息
Trans Am Clin Climatol Assoc. 1993;104:61-72; discussion 72-3.
Abstract
The development and characterization of an animal model to study mechanisms underlying abnormal alcohol-seeking behavior have been described. Raised by genetic means, it demonstrates the importance of genetic factors in this behavior. It has allowed the elucidation of neural pathways and neurotransmitter systems that subserve alcohol-seeking behavior. It offers the potential for screening new medications for the treatment of alcoholism, based upon these kinds of newly discovered knowledge.
摘要
已描述了一种用于研究异常觅酒行为潜在机制的动物模型的开发与特性。通过基因手段培育而成，它证明了遗传因素在这种行为中的重要性。它使得对维持觅酒行为的神经通路和神经递质系统得以阐明。基于这类新发现的知识，它为筛选治疗酒精中毒的新药提供了可能性。
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