DROZEVKINA M S
Bull World Health Organ. 1963;29(1):43-57.
It is only comparatively recently that efforts to isolate and purify stable Brucella phages have met with success. This success has important implications for the epidemiology and possibly the control of brucellosis, and the author has therefore thought it opportune to summarize and review the present state of research on Brucella phages.After giving an outline of the history of Brucella phage isolation, she goes into the methodology of phage isolation from numerous sources, of phage reinforcement, and of determination of the lytic activity of phage. This is followed by a discussion of the biological properties, morphology and typing of Brucella phage, and of lysogeny in Brucella. Finally, she reviews the promising research that is being done on Brucella typing with specific phage and on the use of antiphage serum in diagnosis, and discusses the possible use of phage in the treatment and prevention of brucellosis.
直到最近，分离和纯化稳定的布鲁氏菌噬菌体的努力才取得成功。这一成功对布鲁氏菌病的流行病学以及可能的控制具有重要意义，因此作者认为有必要总结和回顾布鲁氏菌噬菌体的研究现状。在概述了布鲁氏菌噬菌体分离的历史之后，她深入探讨了从众多来源分离噬菌体的方法、噬菌体强化方法以及噬菌体裂解活性的测定方法。接下来讨论了布鲁氏菌噬菌体的生物学特性、形态学和分型，以及布鲁氏菌中的溶原性。最后，她回顾了利用特异性噬菌体进行布鲁氏菌分型以及在诊断中使用抗噬菌体血清的有前景的研究，并讨论了噬菌体在布鲁氏菌病治疗和预防中的可能用途。
