Avlund Kirsten, Pedersen Agnes N, Schroll Marianne
Department of Social Medicine, Institute of Public Health, University of Copenhagen, Denmark.
Psychosom Med. 2003 Sep-Oct;65(5):771-7. doi: 10.1097/01.psy.0000082640.61645.bf.
To analyze whether functional decline from age 80 to 85 is influenced by changes in self-reported tiredness in daily activities in the preceding 5-year period.
A prospective study of 226 75-year-old men and women with 5- and 10-year follow-up in the Western part of Copenhagen County. Tiredness in daily activities was measured at age 75 and 80 by a validated scale. Changes in tiredness from age 75 to 80: 1) Sustained no tiredness, 2) not tired-tired, 3) tired-not tired, 4) sustained tiredness. Functional decline from age 80 to 85:1) Sustained no need of help; 2) need of help at age 85, alive; 3) need of help at age 85 or dead; 4) dead.
The analyses among the survivors showed a slight tendency to an association between having sustained tiredness or development of tiredness from age 75 to 80 and functional decline from age 80 to 85. Persons with sustained tiredness from age 75 to 80 were at significantly larger risk of functional decline and mortality from age 80 to 85. These results were not attenuated when adjusted by the covariates.
The results in the present study indicate that it is important to take continuous complaints about tiredness in daily activities seriously, because this is an early sign of functional decline.
分析80至85岁期间的功能衰退是否受此前5年日常活动中自我报告的疲劳变化影响。
对哥本哈根县西部226名75岁男性和女性进行前瞻性研究，随访5年和10年。在75岁和80岁时用经过验证的量表测量日常活动中的疲劳程度。75至80岁疲劳程度的变化：1）持续无疲劳；2）从无疲劳到有疲劳；3）从有疲劳到无疲劳；4）持续有疲劳。80至85岁的功能衰退情况：1）持续无需帮助；2）85岁时需要帮助且存活；3）85岁时需要帮助或死亡；4）死亡。
对幸存者的分析显示，75至80岁持续有疲劳或出现疲劳与80至85岁功能衰退之间存在轻微关联趋势。75至80岁持续有疲劳的人在80至85岁时功能衰退和死亡风险显著更高。经协变量调整后，这些结果并未减弱。
本研究结果表明，认真对待日常活动中持续出现的疲劳抱怨很重要，因为这是功能衰退的早期迹象。
