Pantoflickova D, Corthésy-Theulaz I, Dorta G, Stolte M, Isler P, Rochat F, Enslen M, Blum A L
Division of Gastroenterology, University Hospital, Lausanne, Switzerland.
Aliment Pharmacol Ther. 2003 Oct 15;18(8):805-13. doi: 10.1046/j.1365-2036.2003.01675.x.
Lactobacillus johnsonii (Lj1) had an in vitro and in vivo inhibitory effect on Helicobacter pylori. Fermented milk containing Lj1 (LC1), coadministered with antibiotics had a favourable effect on H. pylori gastritis.
Evaluate the effect of LC1 intake without antibiotics on H. pylori gastritis.
Fifty H. pylori positive healthy volunteers were randomised in a double-blind study to LC1 or placebo. Gastric biopsies from the antrum and corpus were obtained before, and after 3 and 16 weeks of treatment, for histology and quantitative cultures.
Severity and activity of antral gastritis was reduced after 16-week LC1 intake (pretreatment and 16-week inflammatory cell score: 6.0 +/- 0.8 vs. 5.3 +/- 0.1; P=0.04). H. pylori density decreased in the antrum after LC1 intake (3-week: 4.4 +/- 0.6; 16-week: 4.3 +/- 0.5 log10 colony forming units (cfu) vs. pretreatment 4.5 +/- 0.4 log10 cfu; P=0.04, respectively). Mucus thickness increased after 16 weeks of LC1 consumption (change of mucus thickness with LC1 and placebo in the antrum: 0.6 +/- 1.3 vs. -0.2 +/- 1.0, P=0.01; in the corpus: 0.3 +/- 1.1 vs. -0.6 +/- 1.5, P=0.03).
LC1 intake had a favourable, albeit weak, effect on H. pylori associated gastritis, particularly in the antrum. Regular ingestion of fermented milk containing L. johnsonii may reduce the risk of developing disorders associated with high degrees of gastric inflammation and mucus depletion.
约氏乳杆菌（Lj1）在体外和体内对幽门螺杆菌均有抑制作用。含Lj1的发酵乳（LC1）与抗生素联合使用对幽门螺杆菌性胃炎有良好效果。
评估在不使用抗生素的情况下摄入LC1对幽门螺杆菌性胃炎的影响。
50名幽门螺杆菌阳性的健康志愿者被随机纳入一项双盲研究，分为LC1组或安慰剂组。在治疗前、治疗3周和16周后，采集胃窦和胃体的胃活检组织进行组织学检查和定量培养。
摄入LC1 16周后，胃窦胃炎的严重程度和活动性降低（治疗前和16周时炎症细胞评分：6.0±0.8 vs. 5.3±0.1；P=0.04）。摄入LC1后，胃窦中幽门螺杆菌密度降低（3周时：4.4±0.6；16周时：4.3±0.5 log10菌落形成单位（cfu），而治疗前为4.5±0.4 log10 cfu；P分别为0.04）。摄入LC1 16周后，黏液厚度增加（胃窦中LC1组和安慰剂组黏液厚度变化：0.6±1.3 vs. -0.2±1.0，P=0.01；胃体中：0.3±1.1 vs. -0.6±1.5，P=0.03）。
摄入LC1对幽门螺杆菌相关性胃炎有良好作用，尽管作用较弱，尤其是在胃窦。定期摄入含约氏乳杆菌的发酵乳可能会降低发生与高度胃炎症和黏液减少相关疾病的风险。
