Castaño-Vinyals G, D'Errico A, Malats N, Kogevinas M
Respiratory and Environmental Research Unit, Municipal Institute of Medical Research, Barcelona, Spain.
Occup Environ Med. 2004 Apr;61(4):e12. doi: 10.1136/oem.2003.008375.
Metabolites of pyrene and DNA adducts have been used as biomarkers of high level exposure to polycyclic aromatic hydrocarbons (PAHs). A systematic review was performed to evaluate whether these biomarkers are also valid markers of low level environmental exposure to PAHs. Thirty five studies were identified with more than 10 subjects that evaluated environmental air pollution to PAHs in relation to metabolites of PAHs, mainly hydroxypyrene (1-OHP), PAH-DNA adducts, or protein adducts. PAH metabolites and, to a less extent, PAH-DNA adducts correlated well at the group level with exposure to B(a)P even at low levels of air pollution. The use of these biomarkers should be more widely implemented in combination with more traditional techniques for the assessment of general population exposure to PAHs from ambient air pollution.
芘代谢物和DNA加合物已被用作多环芳烃（PAHs）高剂量暴露的生物标志物。进行了一项系统综述，以评估这些生物标志物是否也是PAHs低水平环境暴露的有效标志物。确定了35项研究，每项研究有10多名受试者，这些研究评估了环境空气污染中的PAHs与PAHs代谢物（主要是羟基芘（1-OHP））、PAH-DNA加合物或蛋白质加合物之间的关系。即使在低水平空气污染情况下，PAH代谢物以及在较小程度上PAH-DNA加合物在群体水平上与苯并[a]芘暴露也有很好的相关性。这些生物标志物的应用应与更传统的技术相结合，更广泛地用于评估普通人群因环境空气污染而接触PAHs的情况。
