恩加里病毒是一种布尼亚姆韦拉病毒重组体，可与非洲大规模出血热疫情相关联。
Ngari virus is a Bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa.
作者信息
Gerrard Sonja R, Li Li, Barrett Alan D, Nichol Stuart T
机构信息
Special Pathogens Branch, Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, USA.
出版信息
J Virol. 2004 Aug;78(16):8922-6. doi: 10.1128/JVI.78.16.8922-8926.2004.
Abstract
Two isolates of a virus of the genus Orthobunyavirus (family Bunyaviridae) were obtained from hemorrhagic fever cases during a large disease outbreak in East Africa in 1997 and 1998. Sequence analysis of regions of the three genomic RNA segments of the virus (provisionally referred to as Garissa virus) suggested that it was a genetic reassortant virus with S and L segments derived from Bunyamwera virus but an M segment from an unidentified virus of the genus Orthobunyavirus. While high genetic diversity (52%) was revealed by analysis of virus M segment nucleotide sequences obtained from 21 members of the genus Orthobunyavirus, the Garissa and Ngari virus M segments were almost identical. Surprisingly, the Ngari virus L and S segments showed high sequence identity with those of Bunyamwera virus, showing that Garissa virus is an isolate of Ngari virus, which in turn is a Bunyamwera virus reassortant. Ngari virus should be considered when investigating hemorrhagic fever outbreaks throughout sub-Saharan Africa.
摘要
1997年和1998年东非发生大规模疾病暴发期间，从出血热病例中分离出两株正布尼亚病毒属（布尼亚病毒科）病毒。对该病毒（暂称为加里萨病毒）三个基因组RNA片段区域的序列分析表明，它是一种基因重配病毒，其S和L片段源自布尼亚姆韦拉病毒，但M片段来自正布尼亚病毒属的一种未鉴定病毒。虽然对从21种正布尼亚病毒属病毒成员中获得的病毒M片段核苷酸序列分析显示出高度的遗传多样性（52%），但加里萨病毒和恩加里病毒的M片段几乎相同。令人惊讶的是，恩加里病毒的L和S片段与布尼亚姆韦拉病毒的L和S片段显示出高度的序列同一性，这表明加里萨病毒是恩加里病毒的一个分离株，而恩加里病毒又是布尼亚姆韦拉病毒的重配病毒。在调查撒哈拉以南非洲各地的出血热疫情时，应考虑恩加里病毒。
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