Ruano-Ravina A, Figueiras A, Barros-Dios J M
Department of Preventive Medicine and Public Health, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain.
Thorax. 2004 Nov;59(11):981-5. doi: 10.1136/thx.2003.018861.
Few epidemiological studies have examined the effect of wine on the risk of lung cancer. A study was therefore undertaken to estimate the effect of wine consumption, both overall and by type of wine, on the risk of developing lung cancer.
A hospital based case-control study was conducted on 319 subjects (132 cases, 187 controls) in 1999-2000. All subjects were interviewed about their lifestyles with particular reference to alcohol consumption and tobacco use. The results were analysed using non-parametric logistic regression. The main outcome measure was the risk of lung cancer associated with consumption of wine and its individual types.
A very slight but significant association was observed between the risk of lung cancer and white wine consumption (odds ratio (OR) 1.20 for each daily glass). Red wine consumption, on the other hand, had an OR of 0.43 (95% CI 0.19 to 0.96), with each daily glass of red wine having an inverse association with the development of lung cancer (OR 0.87 (95% CI 0.77 to 0.99)). There was no apparent association between lung cancer and consumption of beer or spirits.
These results suggest that the consumption of red wine is negatively associated with the development of lung cancer. Further studies are needed to test this finding in cancer induced laboratory animals.
很少有流行病学研究探讨葡萄酒对肺癌风险的影响。因此开展了一项研究，以评估饮酒总量及不同类型葡萄酒的饮用对患肺癌风险的影响。
1999年至2000年，对319名受试者（132例病例，187例对照）进行了一项基于医院的病例对照研究。所有受试者均接受了关于其生活方式的访谈，特别提及了饮酒和吸烟情况。结果采用非参数逻辑回归进行分析。主要观察指标是与饮用葡萄酒及其各类型相关的肺癌风险。
肺癌风险与白葡萄酒饮用之间观察到非常轻微但显著的关联（每日每杯的优势比（OR）为1.20）。另一方面，饮用红酒的OR为0.43（95%置信区间0.19至0.96），每日每杯红酒与肺癌发生呈负相关（OR 0.87（95%置信区间0.77至0.99））。肺癌与饮用啤酒或烈酒之间没有明显关联。
这些结果表明，饮用红酒与肺癌发生呈负相关。需要进一步研究在癌症诱发实验动物中验证这一发现。
