Diego R Brígido, Olmedilla M Pérez, Aroca A Serrano, Ribelles J L Gómez, Pradas M Monleón, Ferrer G Gallego, Sánchez M Salmerón
Center for Biomaterials, Universidad Polité cnica de Valencia, Camino de Vera s/n, 46022, Valencia, Spain.
J Mater Sci Mater Med. 2005 Aug;16(8):693-8. doi: 10.1007/s10856-005-2604-7.
Polymer scaffolds are obtained in which the geometric characteristics (pore size, connectivity, porosity) and the physico-chemical properties of the resulting material can be controlled in an independent way. The interconnected porous structure was obtained using a template of sintered PMMA microspheres of controlled size. Copolymerization of hydrophobic ethyl acrylate and hydrophilic hydroxyethyl methacrylate comonomers took place in the free space of the template, different comonomer ratio gave rise to different hydrophilicity degrees of the material keeping the same pore architecture. The morphology of the resulting scaffolds was investigated by scanning electron microscopy (SEM), the porosity of the material calculated, and the mechanical properties compared with those of the bulk (non porous) material of the same composition.
得到了聚合物支架，其中所得材料的几何特征（孔径、连通性、孔隙率）和物理化学性质可以独立控制。使用尺寸可控的烧结聚甲基丙烯酸甲酯微球模板获得了相互连接的多孔结构。疏水性丙烯酸乙酯和亲水性甲基丙烯酸羟乙酯共聚单体在模板的自由空间中发生共聚，不同的共聚单体比例导致材料具有不同的亲水性程度，同时保持相同的孔结构。通过扫描电子显微镜（SEM）研究所得支架的形态，计算材料的孔隙率，并将其力学性能与相同组成的块状（无孔）材料的力学性能进行比较。
