Kunisue Tatsuya, Watanabe Michio X, Iwata Hisato, Tsubota Toshio, Yamada Fumio, Yasuda Masatoshi, Tanabe Shinsuke
Center for Marine Environmental Studies, Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan.
Environ Pollut. 2006 Apr;140(3):525-35. doi: 10.1016/j.envpol.2005.07.020. Epub 2005 Sep 12.
The present study determined the contamination levels and congener-specific accumulation features of dioxins and related compounds (DRCs) in wild terrestrial mammals such as large Japanese field mice (LJFM), lesser Japanese moles (LJMs), and raccoon dogs (RDs) collected from Kanto region in Japan during 2001. The toxic equivalent quantity (TEQ) levels in the carcasses or adipose tissues were in the order of RDs > or = LJMs > LJFM. Comparison of DRC congener profiles in the three species and principal component analysis (PCA) demonstrated a higher contribution of OCDD, T4CB77, and P5CB118 in LJMs. Analysis of liver-adipose distribution of DRC congeners in RDs showed that livers contained significantly higher TEQs than adipose tissues, indicating that liver is a depository organ and critical for determining the toxicokinetics of DRCs. As for most T4, P5, H6CDD/DFs and for P5CB126, H6CB169 and mono-ortho PCB congeners, their liver/adipose concentration ratios in RDs revealed a tendency to increase with hepatic TEQ levels, suggesting TEQ-dependent hepatic sequestration.
本研究测定了2001年从日本关东地区采集的野生陆生哺乳动物，如大日本田鼠（LJFM）、小日本鼹鼠（LJMs）和貉（RDs）体内二噁英及相关化合物（DRCs）的污染水平和同类物特异性积累特征。尸体或脂肪组织中的毒性当量（TEQ）水平顺序为：RDs≥LJMs＞LJFM。对这三个物种的DRC同类物谱进行比较并通过主成分分析（PCA）表明，OCDD、T4CB77和P5CB118在LJMs中的贡献更大。对RDs体内DRC同类物的肝脏-脂肪分布分析表明，肝脏中的TEQ显著高于脂肪组织，这表明肝脏是一个储存器官，对于确定DRCs的毒代动力学至关重要。至于大多数T4、P5、H6CDD/DFs以及P5CB126、H6CB169和单邻位多氯联苯同类物，它们在RDs中的肝脏/脂肪浓度比显示出随肝脏TEQ水平升高的趋势，表明存在TEQ依赖性肝脏隔离。
