Steven P, Laqua H, Wong D, Hoerauf H
University Eye Hospital of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany.
Br J Ophthalmol. 2006 Mar;90(3):293-5. doi: 10.1136/bjo.2005.078188.
To report on a new postoperative finding after delamination of the internal limiting membrane (ILM) for the treatment of different macular pathologies.
Seven patients are described with paracentral retinal holes, all located temporally to the macula, which developed after pars plana vitrectomy and uncomplicated ILM removal for cystoid macular oedema (n = 3), macular pucker (n = 3), and macular hole (n = 1) with the use of indocyanine green (n = 4), trypan blue (n = 1), triamcinolone acetonide (n = 1), or without dye (n = 1).
The use of dyes has been incriminated in causing iatrogenic damage to the retina. In this series, the new observation of retinal holes in the macular area is thought to be related to the removal of the ILM itself. The authors speculate that ILM delamination may cause a retinal weakening by Müller cell damage; this may be followed by a structural breakdown and, consequently, hole formation.
报告在为治疗不同黄斑病变而进行内界膜(ILM)分层术后的一项新的术后发现。
描述了7例黄斑旁视网膜裂孔患者,所有裂孔均位于黄斑颞侧,这些裂孔是在经平坦部玻璃体切除术及为治疗黄斑囊样水肿(n = 3)、黄斑皱襞(n = 3)和黄斑裂孔(n = 1)而进行的无并发症的ILM剥除术后出现的,其中使用吲哚菁绿的有(n = 4),使用台盼蓝的有(n = 1),使用曲安奈德的有(n = 1),未使用染料的有(n = 1)。
染料的使用被认为会导致对视网膜的医源性损害。在本系列研究中,黄斑区视网膜裂孔的新发现被认为与ILM本身的剥除有关。作者推测ILM分层可能通过米勒细胞损伤导致视网膜变薄;随后可能会发生结构破坏,进而形成裂孔。