Reznick Abraham Z, Shehadeh Naim, Shafir Yair, Nagler Rafael M
Department of Anatomy and Cell Biology, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Arch Oral Biol. 2006 Aug;51(8):640-8. doi: 10.1016/j.archoralbio.2006.02.004. Epub 2006 Apr 18.
The purpose of the current study was to analyze both serum and salivary composition and oxidative stress markers in Type 1 diabetes mellitus (DM) patients.
Twenty consenting patients with DM but otherwise healthy patients aged 13-19 years and 12 healthy controls, matching in age and gender (Group 1), participated in the study. The patients were divided according to those who had controlled diabetes mellitus (Group 2) or uncontrolled diabetes mellitus (Group 3). All were analyzed for saliva composition and antioxidants. Saliva was also analyzed for its levels of superoxide dismutase (SOD) and amylase activity, total IgA and total IgG concentrations and potassium, phosphorus, magnesium and calcium electrolyte concentrations.
A significant correlation was found between the severity of the DM/HbA1c values and the increase in both salivary and/or serum antioxidants (peroxidase, SOD and TAS), and the various TCL parameters (H1, H3, pre-incubation and oxygenation-potential).
The two most important findings of the current study relate to the role of oxidative stress in the pathogenesis of Type 1 diabetes mellitus and to the involvement of salivary glands in the disease. The profound effects of DM on salivary antioxidant parameters may be also of great importance in respect to the diagnosis and evaluation of the disease. The correlation between altered salivary parameters and the severity of the disease may indicate that evaluation of the salivary status of DM patients as part of the assessment of their disease activity and severity is warranted.
本研究的目的是分析1型糖尿病（DM）患者的血清和唾液成分以及氧化应激标志物。
20名年龄在13 - 19岁、同意参与研究且除糖尿病外身体健康的DM患者以及12名年龄和性别匹配的健康对照者（第1组）参与了该研究。患者根据糖尿病得到控制（第2组）或未得到控制（第3组）进行分组。对所有人的唾液成分和抗氧化剂进行了分析。还分析了唾液中的超氧化物歧化酶（SOD）水平、淀粉酶活性、总IgA和总IgG浓度以及钾、磷、镁和钙电解质浓度。
发现DM的严重程度/HbA1c值与唾液和/或血清抗氧化剂（过氧化物酶、SOD和总抗氧化能力）的增加以及各种TCL参数（H1、H3、预孵育和氧合电位）之间存在显著相关性。
本研究的两个最重要发现涉及氧化应激在1型糖尿病发病机制中的作用以及唾液腺在该疾病中的参与。DM对唾液抗氧化参数的深远影响在疾病的诊断和评估方面可能也非常重要。唾液参数改变与疾病严重程度之间的相关性可能表明，将评估DM患者的唾液状态作为评估其疾病活动度和严重程度的一部分是有必要的。
