Qiao Chun-Feng, Han Quan-Bin, Song Jing-Zheng, Mo Shi-Fu, Kong Ling-Dong, Kung Hsiang-Fu, Xua Hong-Xi
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong, PR China.
Chem Pharm Bull (Tokyo). 2006 Jun;54(6):887-90. doi: 10.1248/cpb.54.887.
Two newly-reported benzofuran glycosides, named psoralenoside and isopsoralenoside, along with two major coumarins, psoralen and isopsoralen, were simultaneously determined in twenty-three samples of Fructus Psoraleae collected from different growth areas in China. The quantitative method was validated, and the mean recovery rates from fortified samples (n=5) of psoralenoside, isopsoralenoside, psoralen and isopsoralen, were 96.5%, 97.1%, 100.7%, and 99.3% with variation coefficient of 3.1%, 3.6%, 2.3%, and 2.2%, respectively. An interesting biotransformation relationship between the glycosides and the coumarins was revealed on the basis of the quality analysis results. It was also suggested that psoralenoside and isopsoralenoside should be used as key quality markers for Fructus Psoraleae, together with the commonly used psoralen and isopsoralen.
在中国不同产地采集的23份补骨脂样品中，同时测定了两种新报道的苯并呋喃糖苷（补骨脂苷和异补骨脂苷）以及两种主要香豆素（补骨脂素和异补骨脂素）。对该定量方法进行了验证，补骨脂苷、异补骨脂苷、补骨脂素和异补骨脂素加标样品（n = 5）的平均回收率分别为96.5%、97.1%、100.7%和99.3%，变异系数分别为3.1%、3.6%、2.3%和2.2%。基于质量分析结果揭示了糖苷与香豆素之间有趣的生物转化关系。研究还表明，补骨脂苷和异补骨脂苷应与常用的补骨脂素和异补骨脂素一起作为补骨脂的关键质量标志物。
