一种电压感应水通道。
A voltage-sensor water pore.
作者信息
Freites J Alfredo, Tobias Douglas J, White Stephen H
机构信息
Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, USA.
出版信息
Biophys J. 2006 Dec 1;91(11):L90-2. doi: 10.1529/biophysj.106.096065. Epub 2006 Sep 29.
Abstract
Voltage-sensor (VS) domains cause the pore of voltage-gated ion channels to open and close in response to changes in transmembrane potential. Recent experimental studies suggest that VS domains are independent structural units. This independence is revealed dramatically by a voltage-dependent proton-selective channel (Hv), which has a sequence homologous to the VS domains of voltage-gated potassium channels (Kv). Here we show by means of molecular dynamics simulations that the isolated open-state VS domain of the KvAP channel in a lipid membrane has a configuration consistent with a water channel, which we propose as a common feature underlying the conductance of protons, and perhaps other cations, through VS domains.
摘要
电压传感器（VS）结构域可使电压门控离子通道的孔道根据跨膜电位的变化而打开和关闭。最近的实验研究表明，VS结构域是独立的结构单元。一种电压依赖性质子选择性通道（Hv）显著地揭示了这种独立性，该通道具有与电压门控钾通道（Kv）的VS结构域同源的序列。在此，我们通过分子动力学模拟表明，脂质膜中KvAP通道分离的开放态VS结构域具有与水通道一致的构型，我们认为这是质子以及可能其他阳离子通过VS结构域传导的共同基础特征。
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