Kriparamanan Rammohan, Aswath Pranesh, Zhou Anhong, Tang Liping, Nguyen Kytai T
Department of Biological and Irrigation Engineering, Biological Engineering Program, Utah State University, Logan 84322, USA.
J Nanosci Nanotechnol. 2006 Jul;6(7):1905-19. doi: 10.1166/jnn.2006.330.
Several in vitro and in vivo experiments have shown that nanostructured materials, which mimic the nanometer topography of the native tissues, improve biocompatible responses, and result in better tissue integration in medical implants. Understanding various aspects of nanotopography is extremely important for better designs of these devices. In this review paper, recent progress in the fabrication, characterization, biological responses, and application of nanostructured materials are discussed. Specifically, materials such as ceramics and polymers used to manufacture nanostructured surfaces are briefly introduced. Techniques for fabrication and characterization of nanostructured materials are also explored. Cellular responses such as morphology, alignment, adhesion, proliferation, and profiles of gene expression of various cell types after their exposure to nanofeatured materials are particularly reviewed. Finally, the paper briefly discusses some application of nanostructured materials including those in biosensor and tissue engineering fields.
多项体外和体内实验表明，模仿天然组织纳米级形貌的纳米结构材料可改善生物相容性反应，并使医用植入物实现更好的组织整合。了解纳米形貌的各个方面对于优化这些装置的设计极为重要。在这篇综述论文中，我们讨论了纳米结构材料在制造、表征、生物反应及应用方面的最新进展。具体而言，简要介绍了用于制造纳米结构表面的陶瓷和聚合物等材料。还探讨了纳米结构材料的制造和表征技术。特别综述了各种细胞类型在接触纳米特征材料后的细胞反应，如形态、排列、黏附、增殖以及基因表达谱。最后，本文简要讨论了纳米结构材料的一些应用，包括在生物传感器和组织工程领域的应用。
