北日德兰郡糖尿病视网膜病变研究（NCDRS）2. 非眼科参数与临床显著性黄斑水肿。
The North Jutland County Diabetic Retinopathy Study (NCDRS) 2. Non-ophthalmic parameters and clinically significant macular oedema.
作者信息
Knudsen L L, Lervang H-H, Lundbye-Christensen S, Gorst-Rasmussen A
机构信息
Department of Ophthalmology, Aarhus University Hospital, Aalborg Sygehus Syd, Hobrovej 18-22, DK-9100 Aalborg, Denmark.
出版信息
Br J Ophthalmol. 2007 Dec;91(12):1593-5. doi: 10.1136/bjo.2006.111872. Epub 2007 Jan 3.
BACKGROUND
The influence of non-ophthalmic parameters on the prevalence of clinically significant macular oedema has not been unambiguously established. The present study was initiated with the aim of clarification.
METHODS
This cross-sectional study comprised 656 type 1 and 328 type 2 diabetic subjects undergoing retinopathy screening in the county of North Jutland. The association between the presence of clinically significant macular oedema and blood pressure, HbA1c, BMI, age, onset of diabetes, duration of diabetes, blood-pressure-reducing medication, lipid-lowering medication, neuropathy and urinary albumin excretion was explored using multiple logistic regression analysis.
RESULTS
We found no significant association between the presence of clinically significant macular oedema and any of the examined parameters in type 1 diabetic subjects. In type 2 diabetic subjects, the duration of diabetes, HbA1c, neuropathy and increased urinary albumin excretion was significantly associated with the presence of clinically significant macular oedema.
CONCLUSIONS
The risk factors for clinically significant macular oedema differ in type 1 and type 2 diabetic subjects and can account only in part for this manifestation.
背景
非眼科参数对临床上显著黄斑水肿患病率的影响尚未明确确立。本研究旨在对此进行阐明。
方法
这项横断面研究纳入了在北日德兰郡接受视网膜病变筛查的656例1型糖尿病患者和328例2型糖尿病患者。采用多因素逻辑回归分析探讨临床上显著黄斑水肿的存在与血压、糖化血红蛋白（HbA1c）、体重指数（BMI）、年龄、糖尿病发病时间、糖尿病病程、降压药物、降脂药物、神经病变及尿白蛋白排泄之间的关联。
结果
我们发现1型糖尿病患者中临床上显著黄斑水肿的存在与任何所检查参数之间均无显著关联。在2型糖尿病患者中，糖尿病病程、HbA1c、神经病变及尿白蛋白排泄增加与临床上显著黄斑水肿的存在显著相关。
结论
1型和2型糖尿病患者临床上显著黄斑水肿的危险因素不同，且只能部分解释这一表现。
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