Medina C, Santos-Martinez M J, Radomski A, Corrigan O I, Radomski M W
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.
Br J Pharmacol. 2007 Mar;150(5):552-8. doi: 10.1038/sj.bjp.0707130. Epub 2007 Jan 22.
Nanoparticles are tiny materials (<1000 nm in size) that have specific physicochemical properties different to bulk materials of the same composition and such properties make them very attractive for commercial and medical development. However, nanoparticles can act on living cells at the nanolevel resulting not only in biologically desirable, but also in undesirable effects. In contrast to many efforts aimed at exploiting desirable properties of nanoparticles for medicine, there are limited attempts to evaluate potentially undesirable effects of these particles when administered intentionally for medical purposes. Therefore, there is a pressing need for careful consideration of benefits and side effects of the use of nanoparticles in medicine. This review article aims at providing a balanced update of these exciting pharmacological and potentially toxicological developments. The classes of nanoparticles, the current status of nanoparticle use in pharmacology and therapeutics, the demonstrated and potential toxicity of nanoparticles will be discussed.
纳米颗粒是微小的材料（尺寸小于1000纳米），具有与相同成分的块状材料不同的特定物理化学性质，这些性质使其在商业和医学发展方面极具吸引力。然而，纳米颗粒可在纳米水平上作用于活细胞，不仅会产生生物学上期望的效果，也会产生不良影响。与许多旨在利用纳米颗粒的理想特性用于医学的努力相反，在有意将这些颗粒用于医学目的时，评估其潜在不良影响的尝试有限。因此，迫切需要仔细考虑纳米颗粒在医学应用中的益处和副作用。这篇综述文章旨在对这些令人兴奋的药理学和潜在毒理学进展进行全面更新。将讨论纳米颗粒的类别、纳米颗粒在药理学和治疗学中的应用现状、已证实的和潜在的纳米颗粒毒性。
