Zhao Paul S, Wong Tien Yin, Wong Wan-Ling, Saw Seang-Mei, Aung Tin
Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
Am J Ophthalmol. 2007 Jun;143(6):1047-9. doi: 10.1016/j.ajo.2007.01.050.
To compare the measurement of the central corneal thickness (CCT) by Visante (Carl Zeiss Meditec, Dublin, California, USA) anterior segment optical coherence tomography (AS-OCT) with ultrasound pachymetry.
Population-based, cross-sectional study.
Participants were part of a population-based study of 3280 Malay subjects aged 40 to 80 years in Singapore. Ultrasound pachmetry of CCT was performed on all participants and approximately 10% underwent further evaluation with AS-OCT.
Two hundred and eighty-five consecutive subjects were included, with a mean age of 57.9 (+/- 10.8) years. CCT as measured by ultrasound pachymetry was highly correlated with the equivalent AS-OCT reading (The Pearson correlation coefficient = 0.93, P < .001). However, Bland-Altman analysis showed that CCT as measured by ultrasound pachymetry was significantly higher by 16.5 +/- 11.7 microm (limits of agreement -6.1 to 39.1, P < .001).
CCT measured by Visante AS-OCT was highly correlated with that from ultrasound pachymetry. However, CCT readings by Visante AS-OCT were consistently less than that of ultrasound pachymetry.
比较使用Visante（美国加利福尼亚州都柏林市卡尔蔡司医疗技术公司）眼前节光学相干断层扫描（AS-OCT）测量中央角膜厚度（CCT）与超声测厚法的结果。
基于人群的横断面研究。
参与者是新加坡一项针对3280名年龄在40至80岁的马来族受试者的基于人群的研究的一部分。对所有参与者进行CCT的超声测厚，并对约10%的参与者进一步采用AS-OCT进行评估。
纳入了285名连续的受试者，平均年龄为57.9（±10.8）岁。超声测厚法测量的CCT与AS-OCT的等效读数高度相关（皮尔逊相关系数 = 0.93，P <.001）。然而，布兰德-奥特曼分析显示，超声测厚法测量的CCT显著高出16.5±11.7微米（一致性界限为-6.1至39.1，P <.001）。
Visante AS-OCT测量的CCT与超声测厚法测量的结果高度相关。然而，Visante AS-OCT测量的CCT读数始终低于超声测厚法的读数。
