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单纯疱疹病毒指定的膜蛋白。I. 1型感染细胞中四种糖蛋白前体及其产物的鉴定。

Membrane proteins specified by herpes simplex viruses. I. Identification of four glycoprotein precursors and their products in type 1-infected cells.

作者信息

Spear P G

出版信息

J Virol. 1976 Mar;17(3):991-1008. doi: 10.1128/JVI.17.3.991-1008.1976.

DOI:10.1128/JVI.17.3.991-1008.1976
PMID:176453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC515499/
Abstract

Polypeptide precursors to the major glycoproteins specified by herpes simplex virus type 1 were identified in immunoprecipitation experiments using antisera that reacted specifically with the viral glycoproteins and their precursors. The results demonstrate that the major glycosylated proteins detected in infected cells are derived from four antigenically distinct polypeptides. Three of these polypeptides become glycosylated in two discrete stages, yielding partially glycosylated intermediates and fully glycosylated products. The final products are the predominant species detected in cytoplasmic virions and in plasma membranes. The fourth polypeptide precursor appears to acquire very little carbohydrate and differs in several respects from the other three precursors.

摘要

在免疫沉淀实验中，利用与单纯疱疹病毒1型指定的主要糖蛋白及其前体发生特异性反应的抗血清，鉴定出了这些主要糖蛋白的多肽前体。结果表明，在受感染细胞中检测到的主要糖基化蛋白源自四种抗原性不同的多肽。其中三种多肽在两个不同阶段进行糖基化，产生部分糖基化的中间体和完全糖基化的产物。最终产物是在细胞质病毒粒子和质膜中检测到的主要种类。第四种多肽前体似乎只获得很少的碳水化合物，并且在几个方面与其他三种前体不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/c71259bf9290/jvirol00219-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/38b95deb06f9/jvirol00219-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/cd7ab6fd7a4a/jvirol00219-0333-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/b1446b2d69aa/jvirol00219-0334-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/a3c2b4232de9/jvirol00219-0336-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/0c0e8845cf69/jvirol00219-0338-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/ee9a9d353f72/jvirol00219-0339-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/94f3c2271e47/jvirol00219-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/c71259bf9290/jvirol00219-0343-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/38b95deb06f9/jvirol00219-0331-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/cd7ab6fd7a4a/jvirol00219-0333-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/b1446b2d69aa/jvirol00219-0334-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/a3c2b4232de9/jvirol00219-0336-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/0c0e8845cf69/jvirol00219-0338-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/ee9a9d353f72/jvirol00219-0339-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/94f3c2271e47/jvirol00219-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fbb/515499/c71259bf9290/jvirol00219-0343-a.jpg

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