Palzer A, Ritzmann M, Wolf G, Heinritzi K
Clinic for Swine, Infectious and Epidemic Diseases, Ludwig-Maximilians University, Sonnenstrasse 16, 85764 Oberschleissheim, Germany.
Vet Rec. 2008 Mar 1;162(9):267-71. doi: 10.1136/vr.162.9.267.
The aim of this study was to evaluate the associations between different pathogens in the development of pneumonia and bronchopneumonia in pigs. Samples of bronchoalveolar lavage fluid from 100 pigs showing no clinical signs and 239 pigs with clinical signs of respiratory disease were examined for Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, US-type porcine respiratory and reproductive syndrome virus (PRRSV), EU-type PRRSV, porcine circovirus type 2 (pcv-2), influenza virus type A, alpha-haemolytic Streptococcus species, beta-haemolytic Streptococcus species, Pasteurella multocida, Bordetella bronchiseptica, Haemophilus parasuis and Actinobacillus pleuropneumoniae. These potential pathogens were detected more frequently in the pigs with respiratory problems than in the pigs with no clinical signs. pcv-2 and alpha-haemolytic streptococci were the pathogens most frequently detected; A pleuropneumoniae was isolated in only two cases. There were more often associations between the organisms in the pigs with clinical signs than in the healthy pigs. In particular, alpha-haemolytic streptococci and M hyopneumoniae were both associated with the presence of M hyorhinis, EU-type PRRSV, P multocida and B bronchiseptica, and alpha-haemolytic streptococci also occurred more often in pigs that were already infected with other pathogens. P multocida and B bronchiseptica were both significantly associated with M hyopneumoniae, alpha-haemolytic streptococci, EU-type PRRSV and US-type PRRSV.
本研究的目的是评估不同病原体与猪肺炎和支气管肺炎发生之间的关联。对100头无临床症状的猪和239头有呼吸道疾病临床症状的猪的支气管肺泡灌洗液样本进行检测，以查找猪肺炎支原体、猪鼻支原体、美国型猪繁殖与呼吸综合征病毒（PRRSV）、欧洲型PRRSV、猪圆环病毒2型（pcv - 2）、甲型流感病毒、α - 溶血性链球菌、β - 溶血性链球菌、多杀性巴氏杆菌、支气管败血波氏杆菌、副猪嗜血杆菌和胸膜肺炎放线杆菌。这些潜在病原体在有呼吸道问题的猪中比在无临床症状的猪中更频繁地被检测到。pcv - 2和α - 溶血性链球菌是最常被检测到的病原体；仅在两例中分离出胸膜肺炎放线杆菌。与健康猪相比，有临床症状的猪体内这些微生物之间的关联更为常见。特别是，α - 溶血性链球菌和猪肺炎支原体均与猪鼻支原体、欧洲型PRRSV、多杀性巴氏杆菌和支气管败血波氏杆菌的存在有关，并且α - 溶血性链球菌在已感染其他病原体的猪中出现的频率也更高。多杀性巴氏杆菌和支气管败血波氏杆菌均与猪肺炎支原体、α - 溶血性链球菌、欧洲型PRRSV和美国型PRRSV显著相关。
