Weissenbacher-Lang Christiane, Kureljušić Branislav, Nedorost Nora, Matula Bettina, Schießl Wolfgang, Stixenberger Daniela, Weissenböck Herbert
Institute of Pathology and Forensic Veterinary Medicine, Department of Pathobiology, University of Veterinary Medicine Vienna, Vienna, Austria.
Department of Pathology, Institute of Veterinary Medicine of Serbia, Belgrade, Serbia.
PLoS One. 2016 Jul 18;11(7):e0158479. doi: 10.1371/journal.pone.0158479. eCollection 2016.
Aim of this study was the retrospective investigation of viral (porcine circovirus type 2 (PCV2), porcine reproductive and respiratory syndrome virus (PRRSV), torque teno sus virus type 1 and 2 (TTSuV1, TTSuV2)) and bacterial (Bordetella bronchiseptica (B. b.), Mycoplasma hyopneumoniae (M. h.), and Pasteurella multocida (P. m.)) co-infections in 110 Pneumocystis spp. positive lung samples of Austrian pigs with pneumonia. Fifty-one % were positive for PCV2, 7% for PRRSV, 22% for TTSuV1, 48% for TTSuV2, 6% for B. b., 29% for M. h., and 21% for P. m. In 38.2% only viral, in 3.6% only bacterial and in 40.0% both, viral and bacterial pathogens were detected. In 29.1% of the cases a co-infection with 1 pathogen, in 28.2% with 2, in 17.3% with 3, and in 7.3% with 4 different infectious agents were observed. The exposure to Pneumocystis significantly decreased the risk of a co-infection with PRRSV in weaning piglets; all other odds ratios were not significant. Four categories of results were compared: I = P. spp. + only viral co-infectants, II = P. spp. + both viral and bacterial co-infectants, III = P. spp. + only bacterial co-infectants, and IV = P. spp. single infection. The evaluation of all samples and the age class of the weaning piglets resulted in a predomination of the categories I and II. In contrast, the suckling piglets showed more samples of category I and IV. In the group of fattening pigs, category II predominated. Suckling piglets can be infected with P. spp. early in life. With increasing age this single infections can be complicated by co-infections with other respiratory diseases.
本研究旨在对110份奥地利患肺炎猪的肺样本进行回顾性调查，这些样本中的肺孢子菌属呈阳性，调查其病毒（猪圆环病毒2型（PCV2）、猪繁殖与呼吸综合征病毒（PRRSV）、1型和2型细小病毒（TTSuV1、TTSuV2））和细菌（支气管败血波氏杆菌（B. b.）、猪肺炎支原体（M. h.）和多杀性巴氏杆菌（P. m.））的合并感染情况。51%的样本PCV2呈阳性，7%的样本PRRSV呈阳性，22%的样本TTSuV1呈阳性，48%的样本TTSuV2呈阳性，6%的样本B. b.呈阳性，29%的样本M. h.呈阳性，21%的样本P. m.呈阳性。在38.2%的样本中仅检测到病毒，在3.6%的样本中仅检测到细菌，在40.0%的样本中同时检测到病毒和细菌病原体。在29.1%的病例中观察到与1种病原体合并感染，在28.2%的病例中与2种病原体合并感染，在17.3%的病例中与3种病原体合并感染，在7.3%的病例中与4种不同的感染因子合并感染。断奶仔猪接触肺孢子菌可显著降低与PRRSV合并感染的风险；所有其他比值比均无统计学意义。比较了四类结果：I = 肺孢子菌属 + 仅病毒合并感染，II = 肺孢子菌属 + 病毒和细菌合并感染，III = 肺孢子菌属 + 仅细菌合并感染，IV = 肺孢子菌属单一感染。对所有样本和断奶仔猪年龄组的评估结果显示，I类和II类占主导。相比之下，哺乳仔猪的I类和IV类样本较多。在育肥猪组中，II类占主导。哺乳仔猪在生命早期即可感染肺孢子菌属。随着年龄的增长，这种单一感染可能会因与其他呼吸道疾病的合并感染而变得复杂。
