Wöckel Achim, Abou-Dakn Michael, Beggel Anna, Arck Petra
Department of Gynecology and Obstetrics, University Hospital Ulm, Prittwitzstrasse 43, 89075 Ulm, Germany.
Mediators Inflamm. 2008;2008:298760. doi: 10.1155/2008/298760.
Breastfeeding-associated inflammatory breast diseases appear especially during the first twelve weeks postpartum and are the most common reason for early cessation of breastfeeding. It also becomes increasingly evident that these inflammatory mammary diseases are triggered or perpetuated in a large part by psychosocial stress. Immunological processes taking place during this cascade in the mammary gland and consequences for the breastfeed newborn are mostly yet unknown. This review summarizes insights from studies on modulation of cytokine levels in breast milk during inflammatory processes like milk stasis and mastitis systematically. It also gives an overview on possible pathological effects, which these cytokine changes in the breast milk might have on the newborn.
母乳喂养相关的炎性乳腺疾病尤其在产后头十二周出现，是早期停止母乳喂养的最常见原因。越来越明显的是，这些炎性乳腺疾病在很大程度上是由心理社会压力引发或持续存在的。在此级联反应过程中乳腺内发生的免疫过程及其对母乳喂养新生儿的影响大多仍不为人知。本综述系统总结了诸如乳汁淤积和乳腺炎等炎症过程中母乳中细胞因子水平调节的研究见解。它还概述了母乳中这些细胞因子变化可能对新生儿产生的潜在病理影响。
