Medintz Igor L, Mattoussi Hedi, Clapp Aaron R
Center for Bio/Molecular Science and Engineering, Code 6900, US Naval Research Laboratory,Washington, DC, USA.
Int J Nanomedicine. 2008;3(2):151-67. doi: 10.2147/ijn.s614.
The use of luminescent colloidal quantum dots in biological investigations has increased dramatically over the past several years due to their unique size-dependent optical properties and recent advances in biofunctionalization. In this review, we describe the methods for generating high-quality nanocrystals and report on current and potential uses of these versatile materials. Numerous examples are provided in several key areas including cell labeling, biosensing, in vivo imaging, bimodal magnetic-luminescent imaging, and diagnostics. We also explore toxicity issues surrounding these materials and speculate about the future uses of quantum dots in a clinical setting.
在过去几年中，由于其独特的尺寸依赖性光学特性以及生物功能化方面的最新进展，发光胶体量子点在生物学研究中的应用急剧增加。在本综述中，我们描述了生成高质量纳米晶体的方法，并报告了这些多功能材料的当前和潜在用途。在几个关键领域提供了大量示例，包括细胞标记、生物传感、体内成像、双模态磁发光成像和诊断。我们还探讨了围绕这些材料的毒性问题，并推测了量子点在临床环境中的未来用途。
