Gómez-Verduzco Gabriela, Cortes-Cuevas Arturo, López-Coello Carlos, Avila-González Ernesto, Nava Gerardo M
Universidad Nacional Autónoma de México, México City, México.
Acta Vet Scand. 2009 Mar 19;51(1):11. doi: 10.1186/1751-0147-51-11.
Control and eradication of intestinal infections caused by protozoa are important biomedical challenges worldwide. Prophylactic control of coccidiosis has been achieved with the use of anticoccidial drugs; however, the increase in anticoccidial resistance has raised concerns about the need for new alternatives for the control of coccidial infections. In fact, new strategies are needed to induce potent protective immune responses in neonatal individuals.
The effects of a dietary supplementation of mannan-oligosaccharide (yeast cell wall; YCW) on the local, humoral and cell-mediated immune responses, and intestinal replication of coccidia were evaluated in a neonatal animal model during natural exposure to Eimeria spp. A total of 840 one-day-old chicks were distributed among four dietary regimens: A) Control diet (no YCW) plus anticoccidial vaccine); B) Control diet plus coccidiostat; C) YCW diet plus anticoccidial vaccination; and D) YCW diet plus coccidiostat. Weight gain, feed consumption and immunological parameters were examined within the first seven weeks of life.
Dietary supplementation of 0.05% of YCW increased local mucosal IgA secretions, humoral and cell-mediated immune responses, and reduced parasite excretion in feces.
Dietary supplementation of yeast cell wall in neonatal animals can enhance the immune response against coccidial infections. The present study reveals the potential of YCW as adjuvant for modulating mucosal immune responses.
控制和根除原生动物引起的肠道感染是全球重要的生物医学挑战。使用抗球虫药已实现对球虫病的预防性控制；然而，抗球虫耐药性的增加引发了对控制球虫感染新替代方法需求的担忧。事实上，需要新策略来诱导新生儿个体产生有效的保护性免疫反应。
在自然暴露于艾美耳属球虫期间，在新生动物模型中评估日粮添加甘露寡糖（酵母细胞壁；YCW）对局部、体液和细胞介导免疫反应以及球虫肠道复制的影响。总共840只1日龄雏鸡被分配到四种日粮方案中：A）对照日粮（无YCW）加抗球虫疫苗）；B）对照日粮加抗球虫药；C）YCW日粮加抗球虫疫苗接种；D）YCW日粮加抗球虫药。在生命的前七周内检查体重增加、采食量和免疫参数。
日粮添加0.05%的YCW可增加局部粘膜IgA分泌、体液和细胞介导免疫反应，并减少粪便中的寄生虫排泄。
新生动物日粮添加酵母细胞壁可增强针对球虫感染的免疫反应。本研究揭示了YCW作为调节粘膜免疫反应佐剂的潜力。
