Minervini Fiorenza, Dell'Aquila Maria Elena
Institute of Sciences of Food Production (ISPA), National Research Council (CNR)/ Via G. Amendola 122/O, 70125 Bari, Italy.
Department of Animal Production, University of Bari / Strada Provinciale Casamassima Km3, 70100 Valenzano, Italy.
Int J Mol Sci. 2008 Dec;9(12):2570-2584. doi: 10.3390/ijms9122570. Epub 2008 Dec 11.
Farm animals are exposed to zearalenone through the feed because of the widespread occurrence of this mycotoxin in cereals and clinical reproductive disorders due to mycotoxin effects are often reported in farm animal species. This review describes the metabolism, the mechanistic aspects, the clinical reproductive symptoms and the in vitro effects on functional parameters of oocytes and sperm cells induced by zearalenone and its derivatives in farm animals. The studies on in vitro effects allow to understand the action mechanisms of mycotoxins and, sometime, to explain the in vivo symptoms. The impairment of semen quality and female reproductive function induced by zearalenone could be a factor responsible for the reproductive failure in farm animals.
由于这种霉菌毒素在谷物中广泛存在，农场动物会通过饲料接触到玉米赤霉烯酮，并且经常有报道称农场动物物种会出现因霉菌毒素作用导致的临床生殖障碍。本综述描述了玉米赤霉烯酮及其衍生物在农场动物体内的代谢、作用机制、临床生殖症状以及对卵母细胞和精子细胞功能参数的体外影响。体外影响的研究有助于了解霉菌毒素的作用机制，并且在某些情况下能够解释体内症状。玉米赤霉烯酮引起的精液质量和雌性生殖功能损害可能是导致农场动物繁殖失败的一个因素。
