Figueiredo Luiz T M, Moreli Marcos L, de-Sousa Ricardo L M, Borges Alessandra A, de-Figueiredo Glauciane G, Machado Alex M, Bisordi Ivani, Nagasse-Sugahara Teresa K, Suzuki Akemi, Pereira Luiz E, de-Souza Renato P, de-Souza Luiza T M, Braconi Carla T, Harsi Charlotte M, de-Andrade-Zanotto Paolo M
University of São Paulo School of Medicine, Ribeirão Preto, Brazil.
Emerg Infect Dis. 2009 Apr;15(4):561-7. doi: 10.3201/eid1504.080289.
Hantavirus pulmonary syndrome (HPS) is an increasing health problem in Brazil because of encroachment of sprawling urban, agricultural, and cattle-raising areas into habitats of subfamily Sigmodontinae rodents, which serve as hantavirus reservoirs. From 1993 through June 2007, a total of 884 cases of HPS were reported in Brazil (case-fatality rate 39%). To better understand this emerging disease, we collected 89 human serum samples and 68 rodent lung samples containing antibodies to hantavirus from a 2,500-km-wide area in Brazil. RNA was isolated from human samples and rodent tissues and subjected to reverse transcription-PCR. Partial sequences of nucleocapsid protein and glycoprotein genes from 22 human and 16 rodent sources indicated only Araraquara virus and Juquitiba virus lineages. The case-fatality rate of HPS was higher in the area with Araraquara virus. This virus, which may be the most virulent hantavirus in Brazil, was associated with areas that have had greater anthropogenic changes.
由于城市、农业和畜牧区不断扩张，侵入作为汉坦病毒宿主的稻鼠亚科啮齿动物栖息地，汉坦病毒肺综合征（HPS）在巴西正成为一个日益严重的健康问题。从1993年到2007年6月，巴西共报告了884例HPS病例（病死率为39%）。为了更好地了解这种新出现的疾病，我们从巴西一个宽2500公里的区域收集了89份人类血清样本和68份含有汉坦病毒抗体的啮齿动物肺样本。从人类样本和啮齿动物组织中分离出RNA，并进行逆转录聚合酶链反应。来自22个人类和16个啮齿动物来源的核衣壳蛋白和糖蛋白基因的部分序列仅显示阿拉拉夸拉病毒和朱基蒂巴病毒谱系。在阿拉拉夸拉病毒所在地区，HPS的病死率更高。这种病毒可能是巴西毒性最强的汉坦病毒，与人类活动变化较大的地区有关。
