Zipprich Jennifer, Terry Mary Beth, Liao Yuyan, Agrawal Meenakshi, Gurvich Irina, Senie Ruby, Santella Regina M
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York 10032, USA.
Cancer Res. 2009 Apr 1;69(7):2966-72. doi: 10.1158/0008-5472.CAN-08-3418.
Reactive oxygen species are important in the pathogenesis of many diseases, including breast cancer. Several population-based case-control studies have shown that various biomarkers of oxidative stress are associated with an increase in breast cancer risk. We selected sisters discordant for breast cancer (n=645) from the New York site of the Breast Cancer Family Registry to explore factors that contribute to variation in plasma protein carbonyls, and to determine whether this biomarker is associated with an increase in breast cancer risk among those with a family history. Late age at menarche, hormone replacement therapy use, and Hispanic race were significantly associated with lower plasma protein carbonyl levels in unaffected sisters. Plasma protein carbonyls were associated with an increase in breast cancer risk [Q2 odds ratio (OR), 1.4; 95% confidence interval (CI), 0.8-2.7; Q3 OR, 2.4; 95% CI, 1.1-4.9; Q4 OR, 1.9; 95% CI, 0.8-4.2], although not in a dose-dependent manner. These data suggest that oxidative damage is a risk factor for breast cancer in high-risk women.
活性氧在包括乳腺癌在内的许多疾病的发病机制中都很重要。几项基于人群的病例对照研究表明，氧化应激的各种生物标志物与乳腺癌风险增加有关。我们从乳腺癌家族登记处纽约站点选取了患乳腺癌情况不一致的姐妹（n = 645），以探究导致血浆蛋白羰基变化的因素，并确定该生物标志物在有家族病史的人群中是否与乳腺癌风险增加有关。初潮年龄晚、使用激素替代疗法以及西班牙裔种族与未受影响姐妹较低的血浆蛋白羰基水平显著相关。血浆蛋白羰基与乳腺癌风险增加相关[四分位数2优势比（OR）为1.4；95%置信区间（CI）为0.8 - 2.7；四分位数3 OR为2.4；95% CI为1.1 - 4.9；四分位数4 OR为1.9；95% CI为0.8 - 4.2]，尽管不是呈剂量依赖性。这些数据表明，氧化损伤是高危女性患乳腺癌的一个风险因素。
