应用暴露边际（MoE）方法评估食品中具有遗传毒性和致癌性的物质示例：1-甲基环丙烯及其杂质（1-氯-2-甲基丙烯和 3-氯-2-甲基丙烯）。
Application of the margin of exposure (MoE) approach to substances in food that are genotoxic and carcinogenic - example: 1-methylcyclopropene and its impurities (1-chloro-2-methylpropene and 3-chloro-2-methylpropene).
机构信息
University of Southampton, UK.
出版信息
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S81-8. doi: 10.1016/j.fct.2009.09.024. Epub 2009 Sep 26.
PMID:19786060
Abstract
The chlorinated impurities of 1-methylcyclopropene possess weak mutagenicity and are carcinogenic in rodent bioassays. Dose-response modelling of the data for 1-chloro-2-methylpropene gave a BMDL10 for nasal carcinomas in male rats of 11 mg/kg-bw/day (after correction for the 5 days/week dosage schedule). No human exposure data are available and theoretical estimates had to be used to calculate the MoE. The MoEs ranged from 40,000 to 100,000,000 depending on the assumptions used in the exposure estimation.
摘要
1-甲基环丙烯的氯化杂质具有弱诱变活性，并在啮齿动物生物测定中具有致癌性。对 1-氯-2-甲基丙烯数据的剂量反应建模得出，雄性大鼠鼻腔癌的 BMDL10 值为 11mg/kg-bw/天（经每周 5 天剂量方案校正后）。目前尚无人类接触数据，因此必须使用理论估算来计算 MOE。MOE 值范围为 40000 至 100000000，具体取决于暴露估算中使用的假设。
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