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灰毡毛忍冬的极性和非极性提取物的体外治疗潜力。

Therapeutic Potential of Polar and Non-Polar Extracts of Cyanthillium cinereum In Vitro.

机构信息

School of Biotechnology, Chemical and Biomedical Engineering, VIT University, Vellore 632 014, Tamil Nadu, India.

出版信息

Evid Based Complement Alternat Med. 2011;2011:784826. doi: 10.1093/ecam/nep155. Epub 2011 Jun 23.

DOI:10.1093/ecam/nep155
PMID:19875433
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3137564/
Abstract

Cyanthillium cinereum (Less.) H. Rob. (Asteraceae) has been traditionally known for its medicinal properties, all aspects of which are yet to be exploited. This study was aimed at investigating the therapeutic potential of polar (methanolic and aqueous) and nonpolar (hexane and chloroform) crude extracts of the whole plant. Several parameters including free-radical (DPPH(•), ABTS(•+), H(2)O(2) and (•)OH) scavenging, reducing power, protection of DNA against oxidative damage, cytotoxicity, inhibition of oxidative hemolysis in erythrocytes, total phenolic content and inhibition of lipid peroxidation were examined. All the free-radical generating assay models demonstrated positive scavenging efficiency with differential but considerable magnitudes for the four extracts. However, only the hexane extract showed significant H(2)O(2) scavenging effect. Lipid peroxidation was estimated by thiobarbituric acid-malondialdehyde (MDA) reaction, and a high degree of inhibition was shown by all the extracts. Reducing power of the polar extracts was higher than the non-polar ones. All extracts showed a concentration-dependent increase in phenolic contents. Oxidative damage to erythrocytes was hindered by all extracts in diverse degrees. XTT assay showed that all extracts have mild cytotoxic property. The aqueous extract evidently demonstrated protective effect on pBR322 plasmid DNA against oxidative breakdown. These results suggested the potential of C. cinereum as medicine against free-radical-associated oxidative damage and related degenerative diseases involving metabolic stress, genotoxicity and cytotoxicity.

摘要

灰绿紫菀（Less.）H. Rob.（菊科）因其药用特性而被传统所知，但其所有方面都有待开发。本研究旨在研究整株植物的极性（甲醇和水）和非极性（己烷和氯仿）粗提取物的治疗潜力。考察了几种参数，包括自由基（DPPH(•)、ABTS(•+)、H(2)O(2)和(•)OH）清除、还原能力、保护 DNA 免受氧化损伤、细胞毒性、抑制红细胞氧化溶血、总酚含量和抑制脂质过氧化。所有自由基生成测定模型均表现出对四种提取物的不同但相当大的清除效率。然而，只有己烷提取物显示出对 H(2)O(2)的显著清除效果。通过硫代巴比妥酸-丙二醛（MDA）反应估计脂质过氧化，所有提取物均表现出高度的抑制作用。极性提取物的还原能力高于非极性提取物。所有提取物均表现出浓度依赖性的酚类含量增加。所有提取物均以不同程度抑制了红细胞的氧化损伤。XTT 测定表明，所有提取物均具有轻微的细胞毒性。水提取物明显对 pBR322 质粒 DNA 具有保护作用，可防止氧化破坏。这些结果表明，灰绿紫菀具有作为治疗自由基相关氧化损伤和涉及代谢应激、遗传毒性和细胞毒性的相关退行性疾病的药物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/951e020ea6ee/ECAM2011-784826.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/a7bcb6d02316/ECAM2011-784826.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/1180754b6b42/ECAM2011-784826.008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/a7bcb6d02316/ECAM2011-784826.001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/5e4919584a76/ECAM2011-784826.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/9939fae91294/ECAM2011-784826.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/2ef37b4a29f0/ECAM2011-784826.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/00c0ee3c6201/ECAM2011-784826.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c7d/3137564/1180754b6b42/ECAM2011-784826.008.jpg
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