Upton C J, Milner A D
Department of Neonatal Medicine and Surgery, City Hospital, Nottingham.
Arch Dis Child. 1991 Jan;66(1 Spec No):39-42. doi: 10.1136/adc.66.1_spec_no.39.
Thirty asphyxiated neonates were resuscitated endotracheally with an anaesthetic rebreathing bag. The system was not limited either by pressure or by volume and chest movement was used as the criterion for adequate inflation. Inflation pressure and flow were recorded during resuscitation, and flow was integrated to obtain volume. Median mean pressure over the first 10 inflations was 40 cm H2O and this dropped during later resuscitation to 29 cm H2O. The volume delivered did not change significantly, so volume divided by pressure increased from a median of 0.18 to 0.35 ml/kg/cm H2O. Fourteen infants formed part of their functional residual capacity with artificial ventilation and five with spontaneous breaths. Eleven infants showed no evidence of functional residual capacity formation. In the 22 preterm infants there was a strong association between absence of functional residual capacity formation and later hyaline membrane disease that required ventilation. We suggest that pressures of more than than 30 cm H2O may be helpful during initial resuscitation and that there should be further study of devices using positive end expiratory pressure for resuscitation of preterm infants.
30名窒息新生儿使用麻醉复吸袋进行气管内复苏。该系统不受压力或容量限制,胸部运动被用作充分通气的标准。复苏过程中记录通气压力和流量,并对流量进行积分以获得容量。前10次通气的平均压力中位数为40 cm H2O,在随后的复苏过程中降至29 cm H2O。输送的容量没有显著变化,因此容量除以压力从中位数0.18增加到0.35 ml/kg/cm H2O。14名婴儿通过人工通气形成了部分功能残气量,5名婴儿通过自主呼吸形成了部分功能残气量。11名婴儿没有形成功能残气量的证据。在22名早产儿中,未形成功能残气量与后来需要通气的透明膜病之间存在强烈关联。我们建议,初始复苏期间压力超过30 cm H2O可能有益,并且应该对使用呼气末正压进行早产儿复苏的设备进行进一步研究。