通过核酸杂交对加兹达尔小鼠肉瘤病毒进行表征及分析病毒在细胞中的表达
Characterization of Gazdar murine sarcoma virus by nucleic acid hybridization and analysis of viral expression in cells.
作者信息
Pang R H, Phillips L A, Haapala D K
出版信息
J Virol. 1977 Nov;24(2):551-6. doi: 10.1128/JVI.24.2.551-556.1977.
Gazdar murine sarcoma virus (Gz-MSV) and Moloney murine sarcoma virus (M-MSV) are closely related. The complete M-MSV-specific nucleic acid sequences constituted a major portion of Gz-MSV-specific sequences. The MSV-specific sequences in both Gz-MSV and M-MSV genomes shared homology with hamster leukemia virus nucleic acid sequences. Both rat cells (S+L+) and hamster (S+L-) cells expressed two viral proteins of 68,000 and 70,000 daltons. These proteins were immunologically related to p60 purified from m1 virions of M-MSV.
加兹达尔鼠肉瘤病毒（Gz-MSV）和莫洛尼鼠肉瘤病毒（M-MSV）密切相关。完整的M-MSV特异性核酸序列构成了Gz-MSV特异性序列的主要部分。Gz-MSV和M-MSV基因组中的MSV特异性序列与仓鼠白血病病毒核酸序列具有同源性。大鼠细胞（S+L+）和仓鼠细胞（S+L-）均表达两种分子量分别为68,000和70,000道尔顿的病毒蛋白。这些蛋白在免疫上与从M-MSV的m1病毒粒子中纯化的p60相关。
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