不同年龄组轮状病毒抗体的分布及滴度
Distribution and titres of rotavirus antibodies in different age groups.
作者信息
Elias M M
出版信息
J Hyg (Lond). 1977 Dec;79(3):365-72. doi: 10.1017/s0022172400053201.
Abstract
Three hundred and fifty-seven sera selected at random from hospital patients of all ages were examined for rotavirus antibodies using indirect immunofluorescence (FA) and complement fixation levels (CFT). Three hundred and fourteen of these were also tested for neutralizing antibodies to human rotavirus. Sera from patients admitted with a diagnosis of acute gastroenteritis were excluded from this survey. FA antibodies were found in newborn infants but fell to undetectable titres at 3 months. The highest titres were found in children between the ages of one and three years. In older age groups, the model titre fell gradually with increasing age until, in sera from those above 70 years of age, FA antibodies were almost undetectable. The same pattern was observed with neutralizing antibodies. A high model titre of CF antibodies was only found in sera from those aged one to three years.
摘要
从各年龄段住院患者中随机选取357份血清，采用间接免疫荧光法（FA）和补体结合水平（CFT）检测轮状病毒抗体。其中314份血清还检测了针对人轮状病毒的中和抗体。本次调查排除了诊断为急性肠胃炎的患者血清。在新生儿中发现了FA抗体，但在3个月时降至无法检测到的滴度。最高滴度出现在1至3岁的儿童中。在年龄较大的组中，平均滴度随着年龄的增长而逐渐下降，直到在70岁以上人群的血清中，FA抗体几乎无法检测到。中和抗体也观察到相同的模式。仅在1至3岁人群的血清中发现了高平均滴度的CF抗体。
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