Levallois P, Lavoie M, Goulet L, Nantel A J, Gingras S
Centre de toxicologie du Québec, Sainte-Foy.
CMAJ. 1991 Apr 1;144(7):877-85.
To determine the effect of lead contamination around a lead-reclamation plant on the blood lead levels of children and pregnant women living in the area.
Prevalence study.
Residents living 150 m or less (high-exposure area), 151 to 400 m (intermediate-exposure area) or 401 to 800 m (low-exposure area) southeast from the plant.
All children aged 10 years or less and all pregnant women living in the designated area.
Correlation of venous blood lead levels with soil lead concentrations in the areas in which the subjects lived and with sociodemographic and behavioural factors.
Of the estimated 57 pregnant women 38 (67%) participated: 20 were in the high-exposure area and 18 in the other two areas; their geometric mean blood lead levels were low (0.15 and 0.13 mumol/L respectively). Of the 625 eligible children 510 (82%) participated: 169 were in the high-exposure area, 179 in the intermediate-exposure area and 162 in the low-exposure area; their geometric mean lead levels were 0.43, 0.30 and 0.26 mumol/L respectively. Within each age group children in the high-exposure area had the highest levels. The mean levels for children aged 6 months to 5 years were 0.49, 0.35 and 0.28 mumol/L in the three areas respectively. Within each exposure group children aged 1 to 2 years had the highest levels. No potential confounding variables could explain the relation between blood lead level and soil lead concentration.
The pregnant women's blood lead levels did not seem to be affected by exposure level, but the children's levels were primarily related to the soil lead concentration.
确定铅回收厂周边铅污染对居住在该地区儿童和孕妇血铅水平的影响。
患病率研究。
居住在该厂东南方向150米及以内(高暴露区)、151至400米(中暴露区)或401至800米(低暴露区)的居民。
所有10岁及以下儿童和居住在指定区域的所有孕妇。
受试者居住地区的静脉血铅水平与土壤铅浓度以及社会人口学和行为因素之间的相关性。
估计的57名孕妇中,38名(67%)参与研究:20名在高暴露区,18名在其他两个区域;她们的几何平均血铅水平较低(分别为0.15和0.13微摩尔/升)。625名符合条件的儿童中,510名(82%)参与研究:169名在高暴露区,179名在中暴露区,162名在低暴露区;他们的几何平均铅水平分别为0.43、0.30和0.26微摩尔/升。在每个年龄组中,高暴露区的儿童血铅水平最高。6个月至5岁儿童在三个区域的平均血铅水平分别为0.49、0.35和0.28微摩尔/升。在每个暴露组中,1至2岁儿童的血铅水平最高。没有潜在的混杂变量能够解释血铅水平与土壤铅浓度之间的关系。
孕妇的血铅水平似乎不受暴露水平的影响,但儿童的血铅水平主要与土壤铅浓度有关。