Avunduk C, Suliman M, Gang D, Polakowski N, Eastwood G L
Gastroenterology Division, University of Massachusetts Medical School, Worcester.
Dig Dis Sci. 1991 Apr;36(4):431-4. doi: 10.1007/BF01298870.
To determine whether Helicobacter pylori has an effect on gastroduodenal mucosal prostaglandin generation, mucosal biopsies were obtained from the gastric body, antrum, and duodenal bulb of 30 patients who were undergoing upper gastrointestinal endoscopy for clinical indications. One biopsy from the gastric body and one from the antrum were tested for urease activity (urea broth) and one biopsy from each area including the duodenum was processed for histology. Two other biopsies form each area were incubated and the accumulation of prostaglandin E2 and 6-keto prostaglandin F1 alpha in the incubation medium was measured by radioimmunoassay. Twelve of the 17 H. pylori-positive patients and seven of the 13 H. pylori-negative patients agreed to take bismuth subsalicylate (Pepto-Bismol) two tablets four times a day for four weeks. One week after treatment, these patients again underwent endoscopy and the above studies. This study indicates that: (1) mucosal PGE2 generation may be increased in the duodenum, gastric body, and antrum in H. pylori-positive patients compared to H. pylori-negative patients, and (2) treatment with bismuth subsalicylate for four weeks results in reduction of mucosal PGE2 in the duodenum, gastric body, and antrum of H. pylori-positive patients and fails to eradicate H. pylori or reduce gastric inflammation.
为了确定幽门螺杆菌是否对胃十二指肠黏膜前列腺素的生成有影响，从30例因临床指征接受上消化道内镜检查的患者的胃体、胃窦和十二指肠球部获取黏膜活检组织。对取自胃体的一块活检组织和取自胃窦的一块活检组织进行尿素酶活性检测（尿素肉汤法），对包括十二指肠在内的每个部位的一块活检组织进行组织学检查。对每个部位的另外两块活检组织进行孵育，通过放射免疫分析法测定孵育培养基中前列腺素E2和6-酮前列腺素F1α的积累量。17例幽门螺杆菌阳性患者中的12例和13例幽门螺杆菌阴性患者中的7例同意每天4次、每次两片服用碱式水杨酸铋（必奇），持续4周。治疗1周后，这些患者再次接受内镜检查及上述研究。本研究表明：（1）与幽门螺杆菌阴性患者相比，幽门螺杆菌阳性患者十二指肠、胃体和胃窦的黏膜前列腺素E2生成可能增加；（2）用碱式水杨酸铋治疗4周可使幽门螺杆菌阳性患者十二指肠、胃体和胃窦的黏膜前列腺素E2减少，但未能根除幽门螺杆菌或减轻胃部炎症。
