Prashant Soma, Kumar A S, Basheeruddin D D Mohammed, Chowdhary T N, Madhu B
Department of Dermatology and Venereology, Deccan College of Medical Sciences and Allied Institutes i.e., OwaisiHospital and Princess Esra Hospital, India.
Indian J Dermatol. 2009;54(2):128-31. doi: 10.4103/0019-5154.53186.
An epidemic of chikungunya disease occurred in India during late 2005 through 2006 affecting nearly 1,400,000 people.
To study the cutaneous manifestations in suspected cases of chikungunya disease.
Patients who attended our outpatient departments from January 2006 to September 2006 were prospectively included if they had symptoms of chikungunya disease according to the 'case definition' of the National Institute of Communicable Diseases, Directorate General of Health Services, Government of India. The criteria were an acute illness characterized by the sudden onset of fever and several symptoms such as joint pain, headache, backache, photophobia, and eruption during an epidemic of chikungunya fever in the absence of confirmatory serological tests.
A total of 115 patients (65 men and 50 women) who satisfied the above criteria were enrolled for the study.
An erythematous maculopapular rash subsiding without any sequelae in 3-4 days was the most common cutaneous finding in our patients. Genital ulcers distributed predominantly over the scrotum and base of the penile shaft in men and labia majora in women were the second most common manifestation. Other manifestations included tenderness/edema of hands and feet, grouped hyperpigmented macules over the nose and cheeks, fixed drug eruptions, erythema nodosum, erythema multiformae, generalized urticarial eruptions, and flare up of pre-existing psoriasis and lichen planus.
To conclude, a plethora of cutaneous manifestations were noted in suspected cases of chikungunya disease. Genital ulcers, to the best of our knowledge, have not been reported during the earlier epidemics but have been reported by others during the present one.
2005年末至2006年期间，印度发生了基孔肯雅热疫情，影响了近140万人。
研究疑似基孔肯雅热病例的皮肤表现。
2006年1月至2006年9月期间到我们门诊部就诊的患者，若根据印度政府卫生服务总局国家传染病研究所的“病例定义”有基孔肯雅热疾病症状，则被前瞻性纳入研究。标准为在基孔肯雅热流行期间出现以突然发热起病以及关节疼痛、头痛、背痛、畏光和皮疹等多种症状为特征的急性疾病，且无确诊的血清学检测结果。
共有115名符合上述标准的患者（65名男性和50名女性）被纳入研究。
在我们的患者中，最常见的皮肤表现是3 - 4天内消退且无任何后遗症的红斑丘疹性皮疹。生殖器溃疡是第二常见的表现，主要分布在男性的阴囊和阴茎根部以及女性的大阴唇。其他表现包括手足压痛/水肿、鼻和脸颊上的成簇色素沉着斑、固定性药疹、结节性红斑、多形红斑、全身性荨麻疹样皮疹，以及既往银屑病和扁平苔藓的加重。
总之，在疑似基孔肯雅热病例中观察到了大量皮肤表现。据我们所知，生殖器溃疡在早期疫情中未被报道，但在此次疫情中有其他人报道过。
