应用暴露边际（MoE）方法评估食品中具有遗传毒性和致癌性的物质：示例：丙烯酰胺（CAS 号：79-06-1）。
Application of the Margin of Exposure (MoE) approach to substances in food that are genotoxic and carcinogenic: EXAMPLE: acrylamide (CAS No. 79-06-1).
机构信息
US Food and Drug Administration, USA.
出版信息
Food Chem Toxicol. 2010 Jan;48 Suppl 1:S25-33. doi: 10.1016/j.fct.2009.11.040.
Acrylamide (CH(2)CHCONH(2), CAS Registry No. 79-06-1) is an industrial chemical used since the 1950s as a chemical intermediate in the production of polyacrylamides, which are used as flocculants for clarifying drinking-water and other industrial applications. The neurotoxicity of acrylamide in humans is well known from occupational and accidental exposures. In addition, experimental studies with acrylamide in animals have shown reproductive, genotoxic and carcinogenic properties. Acrylamide may be formed when foods, particularly those that are high in carbohydrates and low in protein, are subjected to high temperatures during cooking or other thermal processing.
丙烯酰胺（CH(2)CHCONH(2)，CAS 注册号 79-06-1）是一种工业化学物质，自 20 世纪 50 年代以来一直被用作生产聚丙烯酰胺的化学中间体，聚丙烯酰胺可用作饮用水澄清和其他工业应用的絮凝剂。丙烯酰胺在人类中的神经毒性已从职业和意外暴露中得到充分证实。此外，丙烯酰胺在动物中的实验研究表明具有生殖毒性、遗传毒性和致癌性。当食物，特别是那些碳水化合物含量高而蛋白质含量低的食物，在烹饪或其他热加工过程中受到高温时，可能会形成丙烯酰胺。
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