越南产大团扇藻（Lyngbya majuscula）中分离得到的与石房蛤毒素相关的代谢物纳他林 A 和 B。
Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.
机构信息
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
出版信息
J Nat Prod. 2010 Apr 23;73(4):784-7. doi: 10.1021/np100002q.
Abstract
Two polyketide metabolites, nhatrangins A (1) and B (2), were isolated from a Vietnamese collection of Lyngbya majuscula. These compounds are related to the aplysiatoxin series of metabolites, which have also been isolated from this species of marine cyanobacterium. The use of 900 MHz cryoprobe NMR allowed the elucidation of the 2D structure of 1 from approximately 0.3 mg of compound. LC-MS analysis was utilized to direct the isolation of additional material as well as the isolation of 2. Conformational analysis was completed using J-based coupling constant analysis and selective NOE experiments.
摘要
从越南产的大团扇藻中分离到两种聚酮类代谢产物，那曲林 A（1）和 B（2）。这些化合物与来自这种海洋蓝藻的aplysiatoxin 系列代谢产物有关。使用 900MHz 冷冻探头 NMR，从大约 0.3mg 的化合物中阐明了 1 的 2D 结构。LC-MS 分析用于指导分离更多的物质以及 2 的分离。构象分析使用 J 耦合常数分析和选择性 NOE 实验完成。
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