Hirsch Annemarie G, Minassian Vatche A, Dilley Anne, Sartorius Jennifer, Stewart Walter F
Geisinger Clinic, Center for Health Research, 100 N. Academy Ave. MC 44-00, Danville, PA 17822, USA.
Int Urogynecol J. 2010 Sep;21(9):1095-102. doi: 10.1007/s00192-010-1164-7. Epub 2010 May 11.
Evidence varies on the relation between parity and urgency or urge incontinence (UUI). We used data from the General Longitudinal Overactive Bladder Evaluation to determine whether differences in case definitions could account for variation in findings.
We simulated case criteria to correspond to studies of urgency, UUI, and parity using data from 1,880 patients. Logistic models were run for each case-control scenario corresponding to previously used case definitions.
Parity was significantly associated with urgency (odds ratios (OR) 1.70; CI: 1.30-2.22) and UUI (odds ratios (OR) 1.87; CI: 1.34-2.60) only when the case criteria included individuals with stress incontinence (SUI). Parity was not associated with UUI when individuals with SUI were excluded or with urgency when individuals with incontinence were excluded.
Neither urgency nor UUI symptoms appear to be associated with parity among women 40 years of age and older. Previous associations appear to be explained by inclusion of individuals with SUI.
关于产次与急迫性尿失禁或尿急失禁（UUI）之间的关系，证据存在差异。我们利用来自膀胱过度活动症综合纵向评估的数据，以确定病例定义的差异是否能够解释研究结果的变化。
我们使用1880名患者的数据，模拟病例标准以对应于关于急迫性、UUI和产次的研究。针对与先前使用的病例定义相对应的每种病例对照情况，运行逻辑模型。
仅当病例标准包括压力性尿失禁（SUI）患者时，产次才与急迫性（比值比（OR）1.70；可信区间：1.30 - 2.22）和UUI（比值比（OR）1.87；可信区间：1.34 - 2.60）显著相关。当排除SUI患者时，产次与UUI不相关；当排除失禁患者时，产次与急迫性不相关。
在40岁及以上女性中，急迫性症状和UUI症状似乎均与产次无关。先前的相关性似乎是由纳入SUI患者所解释的。
