三叶鬼针草根的镇痛和抗炎活性。
Analgesic and anti-inflammatory activity of Argyreia speciosa root.
机构信息
Department of Pharmacology, S.N.J.B'S S.S.D.J. College of Pharmacy Chandwad, Dist. Nashik - 423 101, Maharashtra, India.
出版信息
Indian J Pharmacol. 2009 Aug;41(4):158-61. doi: 10.4103/0253-7613.56066.
OBJECTIVE
To study analgesic and anti-inflammatory activities of a methanolic extract (ME) of Argyreia speciosa (AS) root powder.
MATERIALS AND METHODS
The study was carried out using male albino mice (20-25 gm) and male wistar rats (100-150gm). The ME was prepared using soxhlet extraction process. The effect of ME of A. speciosa was investigated for analgesic activity using acetic acid-induced abdominal constriction, tail immersion method and hot plate method. The anti-inflammatory activity of ME of AS roots was studied using carrageenan-induced rat paw edema.
RESULT
The ME of A. speciosa root was used in pain and inflammation models. The analgesic activity of AS at the dose of (30,100, and 300 mg/kg p.o) showed significant (P<0.01) decrease in acetic acid-induced writhing, whereas ME of A. speciosa at the dose of (100, 300 mg/kg p.o) showed significant (P<0.01) increase in latency to tail flick in tail immersion method and elevated mean basal reaction time in hot plate method. The ME of the A. speciosa at doses (30, 100, and 300mg/kg) showed significant (P < 0.01) inhibition of carrageenan induced hind paw edema in rats.
CONCLUSION
The ME of A. speciosa showed significant analgesic and anti-inflammatory activity in mice and rat.
目的
研究三叶鬼针草（AS）根粉的甲醇提取物（ME）的镇痛和抗炎活性。
材料和方法
该研究使用雄性白化小鼠（20-25 克）和雄性 wistar 大鼠（100-150 克）进行。使用索氏提取法制备 ME。使用醋酸诱导的腹部收缩、尾巴浸泡法和热板法研究 AS 三叶鬼针草 ME 的镇痛作用。研究 AS 三叶鬼针草根 ME 的抗炎活性采用角叉菜胶诱导的大鼠足肿胀。
结果
AS 三叶鬼针草根的 ME 用于疼痛和炎症模型。AS 在剂量为（30、100 和 300mg/kg 口服）时表现出对醋酸诱导的扭体的显著（P<0.01）减少，而 AS 的 ME 在剂量为（100、300mg/kg 口服）时表现出对尾巴浸泡法中尾巴摆动潜伏期的显著（P<0.01）增加和热板法中平均基础反应时间的升高。AS 的 ME 在剂量为（30、100 和 300mg/kg）时表现出对大鼠角叉菜胶诱导的后足肿胀的显著（P < 0.01）抑制作用。
结论
AS 的 ME 在小鼠和大鼠中表现出显著的镇痛和抗炎活性。
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