多溴联苯（PBB）对啮齿动物免疫反应的影响。
Effects of polybrominated biphenyls (PBB) on immune response in rodents.
作者信息
Luster M I, Faith R E, Moore J A
出版信息
Environ Health Perspect. 1978 Apr;23:227-32. doi: 10.1289/ehp.7823227.
Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure severely depressed cell mediated immunity in both mice and rats at the higher dosage levels as indicated by depressed responsiveness of splenic lymphocytes to mitogenic stimulation by polyclonal T-cell activators. Additionally, humoral immunity was depressed in mice at the 30.0 ppm dosage level. Assays for humoral immune functions included antibody production, serum immunoglobulin levels, and mitogenic stimulation of splenic lymphocytes to a polyclonal B-cell activator. These studies indicate that PBB exposure can lead to suppression of both humoral and particularly cell-mediated immune responses.
开展了多项研究，以调查FireMaster FF-1（一种由多溴联苯（PBB）混合物组成的化学阻燃剂）对小鼠和大鼠免疫功能的影响。在为期30天的时间里，动物每天接受22次剂量为0.03、0.3、3.0或30毫克PBB/千克体重的处理。如脾淋巴细胞对多克隆T细胞激活剂的促有丝分裂刺激反应降低所示，在较高剂量水平下，PBB暴露严重抑制了小鼠和大鼠的细胞介导免疫。此外，在30.0 ppm剂量水平下，小鼠的体液免疫受到抑制。体液免疫功能检测包括抗体产生、血清免疫球蛋白水平以及脾淋巴细胞对多克隆B细胞激活剂的促有丝分裂刺激。这些研究表明，PBB暴露可导致体液免疫尤其是细胞介导免疫反应受到抑制。
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