Damsgaard E M, Frøland A, Jørgensen O D, Mogensen C E
Department of Medicine, Fredericia Hospital, Denmark.
BMJ. 1990 Feb 3;300(6720):297-300. doi: 10.1136/bmj.300.6720.297.
Correlation of the urinary albumin excretion rate and the risk of death among elderly subjects.
216 Subjects aged 60-74 whose urinary albumin excretion rate had been determined were followed up 62-83 months later.
Municipality of Fredericia, Denmark.
223 People who had been selected as control subjects for diabetics found during a systematic screening for diabetes of all people aged 60-74 living in the municipality of Fredericia, Denmark. Of these subjects, 216 had an extensive clinical and biochemical examination within a few weeks of selection.
Death.
The median urinary albumin excretion rate was 7.52 micrograms/min. Eight of those with a rate below the median died compared with 23 with a rate equal to or greater than the median (p = 0.0078). The median albumin excretion rate in the 31 who died was 15.00 micrograms/min. Cardiovascular disease was the most common cause of death in both groups. A multivariate regression analysis of survival data was performed using the proportional hazards model. Besides albumin excretion rate, male sex, serum creatinine concentration, and hypertension were found to be of prognostic value.
The association between the albumin excretion rate and mortality that has been described in recent years in patients with diabetes mellitus may be present in elderly people in general, even when other known risk factors are taken into account.
老年受试者尿白蛋白排泄率与死亡风险的相关性。
对216名年龄在60 - 74岁且已测定尿白蛋白排泄率的受试者进行随访，随访时间为62 - 83个月后。
丹麦腓特烈西亚市。
从丹麦腓特烈西亚市所有60 - 74岁人群的糖尿病系统筛查中被选为糖尿病对照受试者的223人。在这些受试者中，216人在入选后的几周内进行了全面的临床和生化检查。
死亡。
尿白蛋白排泄率中位数为7.52微克/分钟。排泄率低于中位数的受试者中有8人死亡，而排泄率等于或高于中位数的有23人死亡（p = 0.0078）。死亡的31人中白蛋白排泄率中位数为15.00微克/分钟。心血管疾病是两组中最常见的死亡原因。使用比例风险模型对生存数据进行多变量回归分析。除白蛋白排泄率外，男性、血清肌酐浓度和高血压被发现具有预后价值。
近年来在糖尿病患者中描述的白蛋白排泄率与死亡率之间的关联，在一般老年人中可能也存在，即使考虑了其他已知风险因素。
