Department of Clinical Dentistry, Center for Clinical Resarch, Faculty of Medicine and Dentistry, University of Bergen, Bergen, Norway.
J Cell Mol Med. 2011 Apr;15(4):718-46. doi: 10.1111/j.1582-4934.2010.01224.x.
This invited review covers research areas of central importance for orthopaedic and maxillofacial bone tissue repair, including normal fracture healing and healing problems, biomaterial scaffolds for tissue engineering, mesenchymal and foetal stem cells, effects of sex steroids on mesenchymal stem cells, use of platelet-rich plasma for tissue repair, osteogenesis and its molecular markers. A variety of cells in addition to stem cells, as well as advances in materials science to meet specific requirements for bone and soft tissue regeneration by addition of bioactive molecules, are discussed.
这篇特邀评论涵盖了对于骨科和颌面骨组织修复至关重要的研究领域，包括正常骨折愈合和愈合问题、组织工程用生物材料支架、间充质和胎儿干细胞、性激素对间充质干细胞的影响、富血小板血浆在组织修复中的应用、成骨作用及其分子标志物。除了干细胞之外，还讨论了多种细胞以及材料科学的进步，通过添加生物活性分子来满足骨和软组织再生的特定要求。
