University of Maryland, College Park, MD 20742, USA.
Neuropsychologia. 2011 Feb;49(3):479-85. doi: 10.1016/j.neuropsychologia.2010.12.015. Epub 2010 Dec 15.
The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.
本研究比较了行为抑制和非抑制青少年在奖励任务中做出选择后,对正性和负性反馈的血氧水平依赖(BOLD)反应。之前在这些相同的研究对象中发现,在预测收益或损失的线索提示下,行为抑制者的纹状体区域的激活增强。然而,没有分析检查实际收益或损失后的反应。与非抑制者相比,当前研究中的行为抑制者对负性反馈的尾状核反应增强,但对正性反馈没有增强,这表明纹状体对反馈的敏感性可能是针对厌恶信息的。此外,与非抑制者相比,行为抑制者在腹内侧前额叶皮层(vmPFC)中表现出正性和负性反馈之间的分化减少。这表明编码奖励价值的能力受到干扰。