Department of Mechanical Engineering, Departments of Surgery & Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON, Canada.
Semin Immunopathol. 2011 May;33(3):257-71. doi: 10.1007/s00281-011-0242-3. Epub 2011 Jan 26.
This paper first presents a brief overview about the mechanism of wear particle formation as well as wear particle characteristics in metal-on-polyethylene and metal-on-metal artificial hip joints. The biological effects of such particles are then described, focusing on the inflammatory response induced by each type of particles as well as on how metal wear products may be the source of a T lymphocyte-mediated specific immune response, early adverse tissue responses, and genotoxicity. Finally, some of the current in vivo models used for the analysis of tissue response to various wear particles are presented.
本文首先简要概述了金属-聚乙烯和金属-金属人工髋关节中磨屑形成的机制以及磨屑的特性。然后描述了这些颗粒的生物学效应，重点介绍了每种颗粒诱导的炎症反应，以及金属磨损产物如何成为 T 淋巴细胞介导的特异性免疫反应、早期不良组织反应和遗传毒性的来源。最后，介绍了目前用于分析各种磨损颗粒对组织反应的一些体内模型。
